Interaction with Polyglutamine Aggregates Reveals a Q/N-rich Domain in TDP-43
نویسندگان
چکیده
منابع مشابه
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.
The identification of pathologic TDP-43 aggregates in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, followed by the discovery of dominantly inherited point mutations in TDP-43 in familial ALS, have been critical insights into the mechanism of these untreatable neurodegenerative diseases. However, the biochemical basis of TDP-43 aggregation and the mechanism of how m...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.125039